Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 81, Issue -, Pages 314-322Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.05.016
Keywords
Sarcophyton; Cembranes; Antiproliferative; HepG2; PC-3
Categories
Funding
- Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [411/150/1433]
- DSR
Ask authors/readers for more resources
Three new cembranoids: sarcophytolol (1), sarcophytolide B (2), and sarcophytolide C (3), along with three known metabolites: 10(14)aromadendrene (4), deoxosarcophine (5), and sarcophine (6) were obtained from the soft bodied coral Sarcophyton glaucum. The structures were determined based on spectroscopic measurements (NMR, UV, IR and MS). Compounds I, 3, and 4 had similar significant cytotoxic effects towards HepG2 (Human hepatocellular liver carcinoma; IC50 = 20 mu M). 2 and 3 showed activity against MCF-7 (Human breast adenocarcinoma; IC50 25 +/- 0.0164 and 29 +/- 0.030 mu M, respectively). Finally, 4 showed potent activity towards PC-3 (Prostate cancer; IC50 9.3 +/- 0.164 mu M). The antiproliferative activity of 1, 3 and 4, can be attributed, at least partly, to their ability to induce cellular apoptosis. (C) 2014 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available