Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 78, Issue -, Pages 281-293Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.03.043
Keywords
Binuclear copper complex; Nucleotide and protein interaction; Cytotoxicity
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Funding
- Council of Scientific and Industrial Research (CSIR), Ministry of Human Resources Development (MHRD), Government of India, New Delhi [01(2684)/12/EMR-II]
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Two new, binuclear copper(II) hydrazone complexes have been synthesized and characterized by various physico-chemical techniques including single crystal X-ray diffraction. Interaction of these complexes with nucleotide and protein were analyzed by in vitro biochemical and electrochemical analysis. Both the complexes exhibited intercalative mode of binding with DNA. Further, gel electrophoresis assay demonstrated the ability of the complexes to cleave the supercoiled pBR322 plasmid DNA to nicked circular DNA form. Cytotoxicity of the complexes performed against a panel of cancer cell lines and a normal cell line proved that these complexes are potentially cytotoxic against the cancerous cell lines, particularly with IC50 as low as 0.7 mu M against HeLa cell line. (C) 2014 Elsevier Masson SAS. All rights reserved.
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