Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 70, Issue -, Pages 613-622Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.10.048
Keywords
RhoA; Rho kinase; Inhibitors; Central nervous system; Fasudil
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Funding
- National Natural Science Foundation of China/RGC Hong Kong Joint Research Scheme [30731160617]
- Guangdong Provincial International Cooperation Project of Science Technology [2012B050300015]
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RhoA/Rho-kinase pathway plays a pivotal role in numerous fundamental cellular functions including contraction, motility, proliferation, differentiation and apoptosis. The pathway is also involved in the development of many diseases such as vasospasm, pulmonary hypertension, cancer and central nervous systems (CNS) disorders. The inhibitors of Rho kinase have been extensively studied since the Rho/Rho-kinase pathway was verified as a target for a number of diseases. Herein, we reviewed the advances in the studies of the roles of Rho/Rho-kinase in diseases and the development of Rho-kinase inhibitors in recent five years. (C) 2013 Elsevier Masson SAS. All rights reserved.
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