Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 59, Issue -, Pages 111-119Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.11.009
Keywords
Benzofuranes; Carboxamides; Antiproliferative activity; Apoptosis; Crystal structure determination
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Funding
- Croatian Ministry of Science, Education and Sports [125-0982464-1356, 098-1191344-2943, 335-0982464-2393, 335-0000000-3532]
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In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-j and 6a-f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 61 induced apoptosis while compound 3i acted through a cell death mechanism other than apoptosis. (C) 2012 Elsevier Masson SAS. All rights reserved.
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