Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 62, Issue -, Pages 206-213Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.12.038
Keywords
Enterovirus 71; Geniposide; Internal ribosome entry site; Fructus gardeniae
Categories
Funding
- China Medical University [CMU98-asia-03]
- China Medical University Hospital [DMR-98-106]
- Republic of China National Science Council [NSC 99-2628-B-039-001-MY3, NSC100-2320-B-039-012-MY3]
Ask authors/readers for more resources
Fructus gardeniae has long been used by traditional Chinese medical practitioners for its anti-inflammatory, anti-oxidant, anti-tumor and anti-hyperlipidemic characteristics. Here we describe our finding that E gardeniae greatly reduces anti-enterovirus 71 (EV71) activity, resulting in significant decreases in EV71 virus yields, EV71 infections, and internal ribosome entry site activity. We also found that geniposide, a primary F. gardeniae component, inhibited both EV71 replication and viral IRES activity. Our data suggest the presence of a mechanism that blocks viral protein translation. According to our findings, F. gardeniae and geniposide deserve a closer look as potential chemopreventive agents against EV71 infections. (C) 2013 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available