Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 60, Issue -, Pages 120-127Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.11.044
Keywords
Coumarin; Monastrol; Hybrids; Antibreast tumor
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Funding
- CSIR
- DST-INSPIRE, New Delhi, India
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Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines. (C) 2012 Elsevier Masson SAS. All rights reserved.
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