Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 69, Issue -, Pages 439-448Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.09.002
Keywords
Andrographolide derivatives; Andographis paniculata; LPL activity; Antidyslipidemic activity; Anti oxidant activity; LDL oxidation
Categories
Funding
- ICMR, New Delhi [59/6/2010/BMS/TRM]
Ask authors/readers for more resources
Andrographis paniculata, native to Taiwan, Mainland China and India, is a medicinal herb, which possesses various biological activities including anti-atherosclerosis. Andrographolide (1) has been identified as one of the active constituents against atherosclerosis. In continuation of our drug discovery program we synthesized few novel derivatives of 1 to improve their antidyslipidemic, LDL-oxidation and antioxidant activity. The tosylated derivative 7 has been turned out to be more potent than the parent compound and comparable activity with marketed antidyslipidemic drugs. (C) 2013 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available