Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue -, Pages 462-466Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.06.060
Keywords
Marine algae; Terpenoids; Gram-positive bacteria; Candida albicans; EAC
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Funding
- King Abdulaziz University, Jeddah [1-150-D 1432]
- DSR
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Three new laurene-type sesquiterpenes, 12-hydroxy isolaurene (1), 8,11-dihydro-12-hydroxy isolaurene (2) and isolauraldehyde (3) were isolated from the organic extract of the red alga Laurencia obtusa. The chemical structures of isolates were determined by interpretation of their spectral data 1D and 2D NMR, UV, IR and MS. The newly isolated compounds were tested for their antimicrobial and antitumor activities. Compounds (1-3) exhibited potent activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus, where 3 proved to be the most active (MIC 35 and 27 mu g/mL, respectively). Moreover, compound 3 exhibited a significant activity against Candida albicans (MIC of 70 mu g/mL) and revealed to have very promising activity in an in vitro model of Ehrlich ascites Carcinoma. (C) 2012 Elsevier Masson SAS. All rights reserved.
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