Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue -, Pages 428-432Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.01.035
Keywords
2-Aminopyrimidines; Aspirin; Thrombosis; Antiplatelet agents
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Funding
- All India Council for Technical Education (AICTE), New Delhi, India [8023/RID/RPS/46/2004-05, 1-10/RID/NDF/PG/36/2009-2010]
- Indian Council of Medical Research (ICMR), New Delhi, India
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A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds. (C) 2012 Elsevier Masson SAS. All rights reserved.
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