Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 58, Issue -, Pages 340-345Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.10.007
Keywords
Thiophene; Thieno[2,3-d]pyrimidines; 1,3,4-Oxadiazoles synthesis; Anti-oxidant activity
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Funding
- UGC-BSR
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This study represents the synthesis of a new series of N-substituted phenyl-5-methyl-6-(5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl)thieno[2,3-d]pyrimidin-4-amine derivatives (4a-l) and substituted phenylamino-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid derivatives (3a-d). The newly synthesized compounds were characterized by H-1 NMR, C-13 NMR, LC-MS and IR analyses. All these novel compounds were screened for their in vitro antioxidant activity by employing DPPH, hydrogen peroxide, and nitric oxide radical scavenging assays. Compounds 4k, 4j, 4d, and 4e showed significant radical scavenging due to the presence of electron donating substituent on both sides of the thienopyrimidine ring enhances the activity and electron withdrawing groups like nitro decrease. (C) 2012 Elsevier Masson SAS. All rights reserved.
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