Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue -, Pages 73-85Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.10.024
Keywords
Copper(II) complexes; DNA binding; Protein binding; Antioxidant; Cytotoxicity
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Funding
- Council of Scientific and Industrial Research, New Delhi, India [01(2216)/08/EMR-II, 21(0745)/09/EMR-II]
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Two new copper(II) complexes have been synthesized by reacting 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (benzoyl) hydrazone (H2L) with CuCl2 center dot 2H(2)O or Cu(NO3)(2)center dot 3H(2)O. The structures of the complexes have been determined by single crystal X-ray diffraction studies. Results obtained using spectroscopic methods strongly suggested that the ligand and its Cu(II) complexes could interact with calf thymus DNA through intercalation. In the case of protein binding, the obtained results indicated that all the three compounds could quench the intrinsic fluorescence of bovine serum albumin through static quenching process. In addition, antioxidant activity tests showed that H2L and its copper(II) complexes possess significant scavenging effect against free radicals. Further, the two copper(II) complexes exhibited effective cytotoxic activity against a panel of human cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.
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