Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity

We are reporting herein for the first time the synthesis of alpha-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to alpha-aminophosphonates using chlorotrimethylsilane (TMSCI) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial strains. (C) 2012 Elsevier Masson SAS. All rights reserved.