Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 12, Pages 5878-5884Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.09.050
Keywords
11H-benzo[a]carbazole; Anticancer; Synthesis; A549; HCT-116; In vivo
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Funding
- National Natural Science Foundation of China (NSFC) [81025020, 81021062]
- Shanghai Municipality [(09ZR1437900), SIMM0907 KF-08]
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A series of novel 11H-benzo[a]carbazole-5-carboxamide derivatives were designed, synthesized and evaluated for their antitumor activity against human cancer A549 and HCT-116 cell lines. Most of the compounds showed potent antitumor activities, and compound 8 displayed remarkable in vitro and in vivo anticancer activity comparable to that of amonafide. (C) 2011 Elsevier Masson SAS. All rights reserved.
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