Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 11, Pages 5237-5257Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.08.042
Keywords
Indolizines; Cycloadditions; Cyclisations; Antimicrobials; Antioxidants; Anti-inflammatory; Anticonvulsants; Enzyme inhibitors; Calcium-entry blockers
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The present review describes the recent progress in synthetic approaches to construct indolizine framework (including partially or wholly reduced ring) and the design of such compounds with potential biological activity. The methods of synthesis are classified as the Tschitschibabin reaction, 1,3-dipolar cycloadditions, cyclisation reactions depending on the position of bond formation, and other methods. The biological activities include antimicrobial activity, antioxidant activity, anti-inflammatory activity, anticonvulsant activity, enzymes inhibition activity and activity as calcium entry blocker. Consequently this review emphasizes the significant development in synthetic methods of indolizines during the current decade, and the importance of indolizines in drug discovery. (C) 2011 Elsevier Masson SAS. All rights reserved.
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