Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 5, Pages 1798-1802Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.02.038
Keywords
TPM-BPs; Anti-bone resorptive activity; Anti-oxidant activity; Spectral analysis
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Funding
- BRNS
- BARC, Mumbai [2010/37C/26/BRNS/1424]
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A new series of tetraphenyl bisphosphonates have been elegantly synthesized by one-pot method and were characterized by elemental analysis, FUR, (1)H, (13)C, (31)P NMR, mass spectra and evaluated for their in vitro antibone resorptive activity by inhibiting growth of osteoclasts. Two bisphosphonates 3g and 3f showed marked inhibition ratio (8 mu M and 10 mu M) and emerged as lead compounds. All compounds were tested for their antioxidant (DPPH scavenging, reducing power and inhibition of lipid peroxidation). They exhibited potent in vitro antioxidant activity dose-dependently. (C) 2011 Elsevier Masson SAS. All rights reserved.
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