Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 9, Pages 4354-4365Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.07.006
Keywords
2,4,6-Trichloro-1,3,5-triazine; 4-Hydroxyquinoline; Piperazine; Antimicrobial activity; Antimycobacterial activity; Anticancer activity
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Funding
- Applied Chemistry Department of S. V. National Institute of Technology, Surat
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A series of novel s-triazine analogs were synthesized and characterized by IR, H-1 NMR, C-13 NMR, F-19 NMR spectroscopy and elemental analysis. Preliminary screening of target compounds against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneria), four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus clavatus, Candida albicans) and Mycobacterium tuberculosis H37Rv indicated that 5d, 5h, 5n, 5p, 5q, 5r, 5s, 5t and 5u were the most active compounds among twenty one studied. Thus, they were further subjected to in vitro biological evaluation against human prostate cancer cell line (DU-145) and the results indicate that two compounds 5n and Ss were markedly active. (C) 2011 Elsevier Masson SAS. All rights reserved.
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