Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 5, Pages 1453-1462Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.01.021
Keywords
Ischemia-reperfusion injury; beta-Carboline alkaloid-peptide conjugates; Antioxidant; Thrombolytic activity
Categories
Funding
- NASA [MSGC R85197]
- Research Excellence Fund [R01121]
- Natural Science Foundation of HeBei, China [062761266]
- Administration of Traditional Chinese Medicine of HeBei Province [2007134]
Ask authors/readers for more resources
We describe a novel class of beta-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that beta-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat. Published by Elsevier Masson SAS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
