Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 3, Pages 914-918Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.01.006
Keywords
5-Fluorouracil; Biomedical polymers; Macromolecular conjugates; Biomedical polyurethanes
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Funding
- Polish State Committee for Scientific Research [MNiSW-0451/B/H03/2010/39, N N209 045139]
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The controlled release of 5-fluorouracil (5FU) from aliphatic poly(amide urethane)s (PURs) was studied in vitro. Linear PUR conjugates were prepared by the reaction between oligo(epsilon-caprolactone) (PCL), oligo-lactide (PLA), copolymers of epsilon-caprolactone (CL) and rac-lactide (rac-LA), dihydroxy(polyethylene adipate) (OEDA) with 1,6-diisocyanatohexane (HDI). Release of 5FU from PURs was found to depend on the nature of oligoester units and consist of soft and hard segments. (C) 2011 Elsevier Masson SAS. All rights reserved.
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