Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 6, Pages 2117-2131Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.02.065
Keywords
Benzo[c]phenanthrolines; Benzo[c]phenanthrolinones; Dialkylaminoalkyl side chains; Cytotoxicity; DNA interactions
Categories
Funding
- Universite de Lille 2/Conseil Regional Nord/Pas-de-Calais
- Institut pour la Recherche sur le Cancer de Lille (IRCL)
- Ligue Nationale Contre le Cancer (Comite du Nord)
Ask authors/readers for more resources
Benzo[c]phenanthrolines and benzo[c]phenanthrolinones substituted by dialkylaminoalkyl side chains at position N5 and C6, respectively, were synthesised and their biological activity evaluated. They displayed interessant cytotoxicity associated with some DNA interactions. However, the low topoisomerase 1 affinity suggests that other cellular targets are responsible for the antiproliferative activity. (C) 2011 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
