Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 3, Pages 1230-1236Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.12.009
Keywords
Antibacterial; Antifungal; Macrocyclic complexes; Isatin
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Funding
- University Grants Commission, New Delhi [32-196/2006(SR)]
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A novel series of macrocyclic complexes of the type [M(C(18)H(14)N(10)S(2))X]X(2) where M = Cr(III), Fe(III) and Mn(III); X = Cl(-), NO(3)(-) and CH(3)COO(-) have been synthesized by [2 + 2] condensation of thiocarbohydrazide and isatin in the presence of trivalent metal salts in methanolic medium by template method. The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic measurements, electronic, NMR, IR and mass spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry for all of these complexes has been proposed. These metal complexes were also tested for their in vitro antimicrobial activities against some bacterial strains viz. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and some fungal strains Aspergillus niger, Aspergillus flavus (molds), Candida albicans, Saccharomyces cerevisiae (yeasts). (C) 2009 Elsevier Masson SAS. All rights reserved.
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