Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 5, Pages 1982-1990Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.01.043
Keywords
C6; Nanomedicine; Titania sol-gel; Silica sol-gel; Chloroplatinic acid; GBM
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Funding
- FONCICYT-CONACyT-Mexico [95095]
- INNN
- UAM
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Novel nanostructured TiO(2) and SiO(2) based biocatalysts, with 3-4 wt. % of Pt have been developed. The obtained materials exhibit a high surface area together with a broad pore size distribution. The method of synthesis allowed obtaining high dispersed platinum metal nanoparticles. In vitro DNA reactivity test of the biocatalysts were carried out by electrophoresis and formation of DNA adducts was observed. The most active biocatalyst was H(2)PtCl(6)/SiO(2). These biocatalysts were also tested in an experimental model of C6 brain tumours in Wistar rats. Administration of the material was made by stereotactic brain surgery to place it directly in the malignant tissue. A significant decrease in tumour size and weight as well as morphologic changes in cancer cells were observed. (C) 2010 Elsevier Masson SAS. All rights reserved.
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