Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 9, Pages 4239-4245Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.06.020
Keywords
Schiff base; Cobalt(II) complex; DNA interaction; Anticancer drug
Categories
Funding
- Razi University Research center
Ask authors/readers for more resources
Binding interaction of a water soluble cobalt(II) complex of a Schiff base, SF, (SF = N,N'-bis(5-[(triphenylphosphonium chloride)-methyl] salicylidine)-o-phenylenediamine) with calf thymus DNA (CT-DNA) has been investigated. The intrinsic binding constant (K-b = 5 x 10(4) M-1) was determined. In comparison with previous study the results indicate that the binding affinity of SF is stronger than its Co(II) complex. Multi-spectroscopic experiments reveal that the binding modes of Co(II) complex in comparison with SF are different; SF may be intercalating between DNA base pairs while its Co(II) complex most likely interact with DNA in an electrostatic binding mode. (C) 2010 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available