Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 7, Pages 3169-3177Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.04.009
Keywords
Thiosemicarbazone; Transition metal; Complex; Crystal structure; Cytotoxicity
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Funding
- Natural Science Foundation of Henan Province [102300410093]
- Foundation for University Young Key Teacher by Henan Province [2009GGJS-025]
- China Postdoctoral Science Foundation [20090460847]
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Transition metal complexes Mn(L-1)(2) (1), Mn(L-2)(2) (2), Co(L-3)(2)Cl 4H(2)O (3), Zn(L-3)(2) DMF (4), Co(HL4)(2)(ClO4)(2) 3H(2)O (5) and Zn(L-5)(2) DMF (6) where HL1 = 2-acetylpyridine thiosemicarbazone, HL2 = 2-acetylpyridine N (4)-methylthiosemicarbazone, HL3 = 2-benzoylpyricline thiosemicarbazone, HL4 = 2-benzoylpyridine N (4)-methylthiosemicarbazone and HL5 = 2-benzoylpyridine N(4)-phenylthiosemicarbazone, have been synthesized. The complexes 1, 2,5 and 6 were characterized by elemental analysis, IR spectra and single-crystal X-ray diffraction studies. Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cancer cell line. (C) 2010 Elsevier Masson SAS. All rights reserved.
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