Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 1, Pages 142-148Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.09.036
Keywords
1,2,3-Triazoles; [3+2] cycloaddition; Cuprous iodide; Antitubercular agents
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Funding
- UGC
- CSIR New Delhi
- DRDO
- DBT New Delhi
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1,4-Disubstituted-1,2,3-triazoles (3-27) have been synthesized by [3+2] cycloaddition of different 2-(azidomethyl)-dihydronaptho(benzo)furans (2a, 2b, 2c and 2d) with different alkynes. All the compounds were screened for antitubercular activity against Mycobacterium tuberculosis H(37)Rv. Compounds 2a, 7,9,12 and 14 exhibited antitubercular activities with MIC ranging from 12.5 to 3.12 mu g/ml. (C) 2009 Elsevier Masson SAS. All rights reserved.
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