Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 11, Pages 4914-4919Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.07.064
Keywords
1-Methyl-1H-pyrazole-4-carboxylic acid; Acyl thiourea; Thiazolylidenes; Anticancer activity; Pyrazole amines
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A series of functionally substituted pyrazole compounds have been synthesized and evaluated in vitro for their antiproliferative effects on a panel of 60 cellular lines, according to the National Cancer Institute screening protocol. Three of the 12 tested compounds showed moderate antitumor activity, one of them being chosen for the 5-dose assay and presented logGl(50) values up to -5.75. (C) 2010 Elsevier Masson SAS. All rights reserved.
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