Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 9, Pages 4280-4287Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.06.028
Keywords
Protease inhibitors; Neutrophil elastase
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Funding
- Heart and Blood Institute of the National Institutes of Health [HL 57788]
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A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE. (C) 2010 Elsevier Masson SAS. All rights reserved.
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