Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 2, Pages 510-518Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.10.037
Keywords
Triazine; Chalcones; Antimicrobial; QSAR; Microdilution
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Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2,4-bis-(phenylamino)-6-[4'-{3 ''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2 ''-propenon-1 ''-yl}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines 7a-e, aminopyrimidines 8a-e and cyanopyridines 9a-e respectively. The products 6a-e, 7a-e, 8a-e and 9a-e were fully characterized by spectroscopic and elemental analysis and also tested for antibacterial activity. (C) 2009 Elsevier Masson SAS. All rights reserved.
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