Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 1, Pages 311-316Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.10.014
Keywords
Platinum(II) complex; Palladium(II) complex; DNA binding; Cytotoxicity in vitro
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Funding
- Natural Science Foundation of China [20671064, 20971090]
- Natural Science Foundation of Liaoning Province [20052014]
- Foundation of Educational Department of Liaoning Province [20060679]
- Foundation of Liaoning Bai Qian Wan Talents Program [2008921054]
- Phenom Foundation of Liaoning colleges and universities [2007R30]
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The complexes [Pt(dmphen)CO3]center dot H2O (1), [Pd(dmphen)CO3]center dot H2O (2) (dmphen is 2,9-dimethyl-1,10-phenanthroline) have been synthesized and characterized. The binding of the complexes with FS-DNA was investigated by UV spectrum and fluorescence spectrum, showing that the complexes have the ability of interaction with DNA of intercalative mode. The intrinsic binding constant K of the complexes with FS-DNA is 1.8 x 10(5) M-1 (1) and 1.6 x 10(4) M-1 (2), respectively. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Evaluation of cytotoxic activity of the complexes against four different cancer cell lines proved that the complexes exhibited cytotoxic specificity and significant cancer cell inhibitory rate. Crown Copyright (C) 2009 Published by Elsevier Masson SAS. All rights reserved.
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