Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 10, Pages 3981-3985Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.04.027
Keywords
Organotin; Salicylaldehyde; Adenine; Schiff base; Antimicrobial; Antitumor
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A new series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph, Bz and L=2-[(9H-Purin-6-ylimino)]-phenol) have been synthesized, characterized by elemental analyses and their solid state configuration has been determined by various spectroscopic (IR,H-1, C-13, Sn-119 NMR, Sn-119m Mossbauer) techniques. The results obtained on the basis of these techniques are in full concurrence with the proposed 2:1 stoichiometry. The title complexes have been screened against various microorganisms, fungi and human cell line KB, the results obtained showed that the bis(2-[(9H-Purin-6-ylimino)]phenolate) diphenyltin(IV) complex exhibited excellent activity against all types of bacteria and fungi used, while bis(2-[(9H-Purin-6-ylimino)]-phenolate) diethyltin(IV) complex was found to have promising antitumor activity. (C) 2009 Elsevier Masson SAS. All rights reserved.
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