Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 9, Pages 3805-3809Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.04.017
Keywords
Multi-component reaction; Tetrahydro-4H-chromenes; 2-Amino-4H-pyrans; Magnesium oxide; Antibacterial activity
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Funding
- Defence Research & Development Organization, New Delhi [ERIP/ER/0505034/M/01/902]
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A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions using magnesium oxide as a catalyst in very good yields. The reaction catalyst, magnesium oxide was reused and recycled without any loss of activity and product yield. All the synthesized compounds were screened for in vitro antibacterial activity, and compounds 3a, 3b, 3f, 4b, 4c, 4d, 4e and 4g showed complete inhibition of bacterial growth at 128 mu g/mL or less and the rest of the compounds exhibited incomplete inhibition. (C) 2009 Elsevier Masson SAS. All rights reserved.
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