Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 9, Pages 3777-3783Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.04.046
Keywords
1,2,3-Triazole derivatives; Diazo compounds; Cantagalo virus; Anti-poxvirus agents; Molecular structure; X-ray crystallography
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Funding
- FAPERJ
- CNPq
- International Foundation for Science
- CAPES
- CNPq-PIBIC
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This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazides, 4, on Cantagalo virus replication. 1-(4-Fluoro-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazide, 4e, exhibited a significant antiviral effect. Characterization of all compounds was confirmed by IR, H-1 and C-13 spectroscopies and elemental analysis. In addition, molecular structure of 4e was also reported. (C) 2009 Elsevier Masson SAS. All rights reserved.
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