Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 12, Pages 5099-5102Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.07.016
Keywords
Cytotoxicity; RFC; PFC; LIF; Palladium(II) complexes; 1,10-Phenanthroline
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The biological activity of previously synthesized compounds [(phen)(3)(H+)(2)(NO3-)(2) (1), Pd(5-NH2-phen)(2)(NO3)(2) (2) and Pd(phen)(2)(NO3)(2)(H2O) (3)] was investigated in vivo. The three compounds did not show any histological alterations in the observed lung, liver, spleen and lymph nodes of White Wistar rats. The propidium iodine staining did not discover any cytotoxic effect of the tested derivatives. The tests for immunological response predominantly showed stimulation of the anti body-producing B-cells and lower or no stimulation of the T-cells. The LIF-test showed better stimulation of all lymphocytes with 1, followed by 2 and 3. Substance 3 showed highest stimulating effect on B-cell blood lymphocytes in all doses (maximum in the lowest dose), whereas the impact of 2 is weaker and that of I is the weakest. The T-cell immune response after treatment with substance I is best influenced by dose of I mg in the spleen cell-fraction, followed by 3 (5 mg). (C) 2009 Elsevier Masson SAS. All rights reserved.
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