Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 12, Pages 4944-4953Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.08.007
Keywords
Fluorinated ureas; Synthesis; Anticancer activity
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Funding
- Russian Foundation for Basic Research [98-03-33007]
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A number of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and -benzothiazolyl ureas have been synthesized and evaluated for their in vitro antiproliferative activities against the human cancer cell lines at the National Cancer Institute (NCI, USA). The activity was shown for compounds 8a,c and 9a-c. The most sensitive cell lines relative to the tested compounds are: 8c PC-3 (prostate cancer, log GI(50) -7.10), 9c SNB-75 (CNS cancer, log GI(50) -5.84), 9b UO-31 (renal cancer, log GI(50) -5.66), and SR (leukemia, log GI(50) -5.44) human cancer cells. (C) 2009 Elsevier Masson SAS. All rights reserved.
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