Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 43, Issue 11, Pages 2373-2379Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.01.037
Keywords
Lanosta-8,23E-diene-3 beta,22R,25-triol; Lanosta-7:9(11),23E-triene-3 beta,22R,25-triol; 3 beta-Hydroxylanosta-8,24-dien-21-al; EBV-EA activation; Mouse-skin carcinogenesis assay
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Funding
- Ministry of Educations, Sports and Culture, Japan
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Two new lanostane-type triterpenoids, 1 and 2 besides two known lanostane-type triterpenoids, 3 and 4 were isolated from the sclerotia of Inonotus obliquus. Their structures were determined to be lanosta-8,23E-diene-3 beta,22R,25-triol (1) and lanosta-7:9(11),23E-triene-3 beta,22R,25-triol (2) by spectral data. These compounds were tested for their anti-tumor-promoting activity using a short-term in vitro assay for EBVEA activation induced by TPA. Compounds 1, 2 and 4 were stronger than the positive control, oleanolic acid. The most abundant compound 4 was investigated for the inhibitory effect in a two-stage carcinogenesis test on mouse skin using DMBA as an initiator and TPA as a promoter. Compound 4 was found to exhibit the potent anti-tumor promoting activity in the in vivo carcinogenesis test. (C) 2008 Elsevier Masson SAS. All rights reserved.
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