Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 35, Pages 6117-6125Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201402819
Keywords
Carbene ligands; Gold; Imidazolium salts; Cytotoxicity; Enzyme inhibition
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Funding
- Ministerio de Ciencia e Innovacion of Spain [CTQ2012-31335, TEC2011-29140-C03-02]
- Generalitat de Catalunya [2009SGR158]
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Seven imidazolium salts have been synthesized from octadecylimidazole (Im18). These salts differ in the length of the alkyl chain length bound to the second nitrogen atom of the imidazolium ring [R = Me, Et, iPr, Pr, Bu, decyl (Dec), octadecyl] and were used as synthetic precursors to obtain two series of gold(I) carbene complexes (AuNHC). The first series contains one labile ligand at the second coordinative position {monocarbene, [AuCl(NHC)]}, and the second one comprises dicarbene complexes. Their biological activity has been evaluated with respect to two different cell lines, and thioredoxin reductase (TrxR) inhibition has also been evaluated for selected examples. Distinct effects have been observed for the imidazolium salts and monocarbene derivatives.
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