Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 21, Pages 3293-3297Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201402408
Keywords
Vanadium; Protein adducts; Medicinal chemistry; EPR spectroscopy; Density functional calculations
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BD/77894/2011, PEst-C/EQB/LA0006/2013, PEst-OE/QUI/UI0100/2013]
- European Community
- Fundação para a Ciência e a Tecnologia [SFRH/BD/77894/2011] Funding Source: FCT
Ask authors/readers for more resources
The biological activity of vanadium complexes, namely, as insulin enhancers, is well known. We report a combined X-ray crystallography, electron paramagnetic resonance, and density functional theory study of the interaction of vanadium picolinate complexes with hen egg white lysozyme (HEWL). We show that the (VO)-O-IV(pic)(2) complex covalently binds to the COO- group of the side chain of Asp52 of HEWL. The long V-IV=O bond obtained in the X-ray study is explained to be due to reduction of V-IV to V-III during exposure of the crystals to the intense X-ray beam.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
