Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 34, Pages 5919-5927Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201300685
Keywords
Cytotoxicity; DNA binding; Copper; Structure elucidation; Chirality
Categories
Funding
- State Key Laboratory of Coordination Chemistry of Nanjing University
- Nanjing Forestry University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Two chiral copper-(II) complexes [Cu(L)(2)Cl]Cl (1) and [Cu(L)(2)Br]Br (2) [L = N-[(pyridin-2-ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the Cu-II ions in 1 and 2 can be described as an intermediate between squarepyramidal and trigonal-bipyramidal. DNA binding studies suggest that the complexes interact with salmon-sperm DNA. through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin-derivative-based simple Schiff base complexes with strong anticancer potential.
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