Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 27, Pages 4334-4341Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201200599
Keywords
Rhenium; Aminopolycarboxylate ligands; Ligand design; Isomer resolution; Imaging agents
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Funding
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases [R37 DK38842]
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The reaction of an aminopolycarboxylate ligand, aspartic-N-monoacetic acid (ASMA), with [Re(CO)3(H2O)3]+ was examined. The tridentate coordination of ASMA to this ReI(CO)3 precursor yielded fac-Re(CO)3(ASMA) as a mixture of diastereomers. The chemistry is analogous to that of the TcI(CO)3 complex, which yields fac-99mTc(CO)3(ASMA) under similar conditions. The formation, structure, and isomerization of fac-Re(CO)3(ASMA) products were characterized by HPLC, 1H NMR spectroscopy, and X-ray crystallography. The two major fac-Re(CO)3(ASMA) diastereomeric products each have a linear ONO coordination mode with two adjacent five-membered chelate rings, but they differ in the endo or exo orientation of the uncoordinated acetate group, in agreement with expectations based on previous studies. Conditions have been identified for the expedient isomerization of fac-Re(CO)3(ASMA) to a mixture consisting primarily of one major product. Because different isomeric species typically have different pharmacokinetic characteristics, these conditions may prove useful for the practical isolation of a single 99mTc(CO)3(ASMA) species, thus allowing the isolation of the isomer that has optimal imaging and pharmacokinetic characteristics. This information will aid in the design of future 99mTc radiopharmaceuticals.
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