Dynamic Constitutional Hybrid Materials - Confined Guanosine Ribbons within Mesoporous Silica

Hydrogen-bonded guanosine (G) dynamic supramolecular architectures exchange between different polymorphs such as G-ribbons, G-quartets and G-quadruplexes. Oriented mesoporous silica can be used as a scaffolding matrix to orient and to stabilize lipophilic guanosine-ribbons in confined conditions. The interface between the lipophilic G-ribbons and the functionalized silica mesopores is based on reversible hydrophobic interactions. This contributes to the high level of adaptability and correlativity of the self-organization of the supramolecular G-ribbons and the oriented mesoporous silica systems. Biomimetic-type hybrids, in which such structures are extremely stable and robust, can be generated by using this strategy.