Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 36, Pages 5960-5965Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201201026
Keywords
Nanomaterials; Nanoparticles; Imaging agents; Magnetic resonance imaging; Ligand effects; Manganese
Categories
Funding
- Ministry of Health and Welfare, the Republic of Korea [A085136]
Ask authors/readers for more resources
Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available