Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 32, Pages 4931-4947Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201100376
Keywords
Metal complexes; Polypyridyl ligands; Transition metals; Drug design; Antitumor agents
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Funding
- European Research Council (ERC) BIO-INCMED
- Marie Curie Intraeuropean Fellowship [220281 PHOTORUACD]
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Polypyridyl metal complexes have optical properties that have been exploited in a wide range of biological and technological applications. Their structural diversity, chemical and redox properties provide a unique opportunity for designing new anticancer agents. Despite this great potential, relatively little is known about the cytotoxic effects of metal polypyridyl complexes, at least in comparison with other classes of coordination and organometallic compounds. This review uses selected examples to illustrate the most recent research carried out on this class of complexes as enzyme inhibitors and cytotoxic agents.
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