Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 6, Pages 843-847Publisher
WILEY-BLACKWELL
DOI: 10.1002/ejic.200901039
Keywords
Sensors; Copper; Fluoresence; Nanoparticles; Silica
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Funding
- WCU [R32-2008-000-20003-0]
- Ministry of Education, Science and Technology, S. Korea
- KRF [KRF-2005-070-C00089]
- Ewha Womans University
- National Research Foundation of Korea [2005-070-C00089] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Fluorescein-functionalized silica nanoparticles (1) were prepared by sol-gel reaction, and their optical sensing abilities were Studied towards finding a new type of synthetic fluorogenic chemosensor for imaging Cu2+ ions in living cells. Interestingly, upon addition of Cu2+ in a H2O suspension of 1 at pH 7.4, 1 displays large chelation-enhanced quenching (CHEQ) effects with Cu2+. With the exception of Cu2+, no significant fluorescence intensity changes were observed in the experiments with the other metal ions. These findings confirm that 1 call be useful as a fluorogenic-sensing material for the selective detection of Cu2+ in the presence of other metal ions, This is a rare example of chromogenic sensing of a specific metal ion by functional inorganic nanomaterials. The emission change observed for chemosensor I in the presence of Cu2+ is reversible by the addition of EDTA. Furthermore, the fluorescein-functionalized silica nanoparticles act as a new type of synthetic fluorogenic chemosensor for imaging Cu2+ ions in living cells.
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