Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 44, Issue 7, Pages 1886-1895Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201344279
Keywords
CD4(+) T cells; CD8(+) T cells; Interferon regulatory factor 4; T-cell differentiation; T-cell subsets
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Funding
- Deutsche Forschungsgemeinschaft [HU 1824/2-1, SFB/TR22]
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Interferon regulatory factor 4 (IRF4) is a transcription factor that is expressed in hematopoietic cells and plays pivotal roles in the immune response. Originally described as a lymphocyte-specific nuclear factor, IRF4 promotes differentiation of naive CD4(+) T cells into T helper 2 (Th2), Th9, Th17, or T follicular helper (Tfh) cells and is required for the function of effector regulatory T (eTreg) cells. Moreover, IRF4 is essential for the sustained differentiation of cytotoxic effector CD8(+) T cells, for CD8(+) T-cell memory formation, and for differentiation of naive CD8(+) T cells into IL-9-producing (Tc9) and IL-17-producing (Tc17) CD8(+) T-cell subsets. In this review, we focus on recent findings on the role of IRF4 during the development of CD4(+) and CD8(+) T-cell subsets and the impact of IRF4 on T-cell-mediated immune responses in vivo.
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