Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 42, Issue 5, Pages 1080-1088Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201142205
Keywords
CD8+T cells; Differentiation; Memory; T-cell help
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CD8+ T cells play an important role in controlling pathogenic infections and are therefore key players in the immune response. It has been shown that among other factors CD4+ T cells can shape the magnitude as well as the quality of primary and/or secondary CD8+ T-cell responses. However, due to the complexity and the differences among diverse immunization or infection models, the overall requirement, the time points, as well as the specific mechanism(s) of CD4+ T-cell help may differ substantially. Here, we summarize current knowledge about the differential requirement of CD4+ T-cell help in promoting primary CD8+ T-cell responses as well as establishing functional memory CD8+ T cells in various experimental settings.
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