Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 42, Issue 6, Pages 1429-1435Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201142286
Keywords
Cell trafficking center dot Cellular immunology center dot Lymph nodes center dot T-cell receptor center dot Treg cells
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Funding
- NIH [T32 DK07006-35, AI37691, AI41521]
- Arthritis Foundation
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CD4+Foxp3+ regulatory T (Treg) cells are required for the maintenance of self-tolerance, as demonstrated by profound autoimmunity in mice and humans with inactivating Foxp3 mutations. Recent studies demonstrate that Treg cells are anatomically compartmentalized within secondary lymphoid organs based on their TCR repertoire and specific organ-protective function; however, whether this reflects differential homing or in situ selection is not known. Here, using Foxp3-GFP reporter mice, we have examined the ability of polyclonal Treg cells from cervical LNs to return to their site-of-origin following adoptive transfer to nonlymphopenic congenic recipients. We find that bulk cervical LN Treg cells do not home directly to cervical LNs but rather accumulate site specifically over time following transfer. Site-specific enrichment is both more rapid and more pronounced among a population of recently activated (CD69+) Treg cells. These data suggest that compartmentalization of Treg cells within secondary lymphoid organs may be governed by antigen recognition and implicate CD69 as a potential marker of recently activated Treg cells recognizing locally expressed antigens.
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