Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 42, Issue 4, Pages 822-825Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201242466
Keywords
Candida; Complement; Cytokine inflammation; C5a; PRa1
Categories
Ask authors/readers for more resources
Complement is the central host defense system that clears invading microbes and balances homeostasis. Pathogenic microbes such as Candida albicans have to breach this efficient and important immune defense layer in order to propagate within the host and to establish an infection. Knowing exactly how the activated complement cascade responds to and attacks microbial invaders is central to understanding the immune battle and the infection process. This also allows a better understanding of how Candida counteracts the individual steps of host innate immunity. Ultimately this knowledge will allow the design of appropriate therapeutic molecules. In this issue Cheng et al. [Eur. J. Immunol. 2012. 42: 993-1004] identify a new cellular effect of the activated human complement system in the defense against the fungal pathogen C. albicans. The authors show that the complement activation fragment C5a, which is formed in response to Candida infection, induces the cellular release of the inflammatory cytokines IL-6 and IL-1 beta.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available