Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 41, Issue 9, Pages 2482-2485Publisher
WILEY
DOI: 10.1002/eji.201141740
Keywords
Inflammation; MicroRNAs; Resolution of inflammation; Toll-like receptors
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Toll-like receptors (TLRs) signal the presence of pathogens and tissue injury, triggering the inflammatory process in macrophages. The goal of inflammation is to resolve the injury and return the body to homeostasis. MicroRNAs are an important group of regulators of TLR signaling and several are induced by TLRs in macrophages. These TLR-induced microRNAs target signaling components in the TLR pathway, thereby producing a negative feedback loop, and they are therefore prime candidates for the initiation of repair. Importantly, their dysregualtion may be important for chronic inflammation, which in turn can lead to autoimmunity and cancer, as discussed in this Viewpoint.
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