Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 41, Issue 12, Pages 3627-3631Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201141876
Keywords
Nod2; Nucleotide-binding domain leucine-rich repeat proteins (NLR); Toxoplasma gondii
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Funding
- NIH [R01DK074738, R01AI071319, U01AI077887]
- FAPESP [10/50959-4]
- INCTV-CNPq
- Cancer Research Institute
- Claudia Adams Barr Award
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Nod2 belongs to the nucleotide-binding domain leucine-rich repeat family of proteins and senses bacterial cell wall components to initiate innate immune responses against various pathogens. Recently, it has been reported that T-cell-intrinsic expression of Nod2 promotes host defense against Toxoplasma gondii infection by inducing type 1 immunity. Here, we present results that demonstrate that Nod2 does not play a role in the defense against T. gondii infection. Nod2-deficient mice were fully capable of inducing Th1 immune responses and did not show enhanced susceptibility to infection. Upon TCR stimulation in vitro, Nod2-deficient CD4(+) T cells showed normal activation, IL-2 production, proliferation, and Th1/2 differentiation. Nod2 mRNA and protein were expressed in CD4(+) T and CD8(+) T cells at substantial levels. Therefore, Nod2, although expressed in CD4(+) T cells, does not have an intrinsic function in T-cell activation and differentiation.
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