Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 41, Issue 9, Pages 2585-2595Publisher
WILEY
DOI: 10.1002/eji.201141540
Keywords
CD8(+) DC; CD103; Cross-presentation; Granulocyte-macrophage colony-stimulating factor; Listeria monocytogenes
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Funding
- National Health and Medical Research Council of Australia (NHMRC) [575543, 637324, 1007703]
- Diabetes Australia
- Juvenile Diabetes Research Foundation
- NHMRC Independent Research Institutes [361646]
- Victorian State Government
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Resident CD8(+) DCs perform several functions, including cross-presenting antigen and rapidly engulfing the Gram-positive intracellular pathogen Listeria monocytogenes. Little is known about how these functions of CD8(+) DCs are modulated. Here, we show that granulocyte-macrophage CSF (GM-CSF), a cytokine that exists at low levels at steady state but is elevated during infection and inflammation, enhances cross-presentation and rapid uptake of L. monocytogenes by resident CD8(+) DCs. This previously unrecognized functional enhancement of CD8(+) DCs by GM-CSF was independent of promoting DC survival in vitro. Enhancement of these functions by GM-CSF was also marked by CD103 expression on CD8(+) DCs that was strongly regulated by GM-CSF. Our findings not only identify GM-CSF as a key molecule regulating CD8(+) DC function, but also as a factor responsible for functional heterogeneity of CD8(+) DCs that is at least substantially demarcated by CD103 expression.
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