Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 40, Issue 3, Pages 616-619Publisher
WILEY
DOI: 10.1002/eji.200940168
Keywords
Danger signals; Inflammasome; Inflammation; Oxidative stress
Categories
Funding
- Human Frontier Science Program
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Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1 beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.
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